Trending Topic

A digital rendering of a human brain with highlighted neural pathways and electric activity, visualizing brain function.
18 mins

Trending Topic

Developed by Touch
Mark CompleteCompleted
BookmarkBookmarked
Pavel Burko, Ilias Miltiadis, Mahsa Alavi

Amyotrophic lateral sclerosis (ALS) is characterized by the degeneration of both upper and lower motor neurons, which ultimately leads to muscle weakness, atrophy, spasticity and contractures.1 ALS typically manifests in the 50–60 years age range, although familial cases may present in late adolescence or early adulthood.2 The time from the first symptom to diagnosis is approximately 10–16 […]

Francesco Saccà, EAN 2022: Improving quality of life for patients with generalized myasthenia gravis – ADAPT trial findings

Share
Facebook
X (formerly Twitter)
LinkedIn
Via Email
Mark CompleteCompleted
BookmarkBookmarked
Copy LinkLink Copied
Published Online: Jul 8th 2022

The ADAPT trial (NCT03669588) supported US Food and Drug Administration approval of efgartigimod alfa-fcab in generalized myasthenia gravis. Dr Francesco Saccà (University of Naples Federico II, Naples, Italy) discussed the findings of the study, in terms of health-related quality-of-life outcomes.

Questions:

1. What are the current challenges in managing cases of generalized myasthenia gravis? (00:14)

2. What did the ADAPT trial aim to demonstrate in patients with generalized myasthenia gravis? (02:21)

3. What effect on patient quality of life has efgartigimod demonstrated? (04:16)

4. How will these findings translate into care strategies for generalized myasthenia gravis? (05:35)

The abstract titled ‘Efgartigimod improved quality-of-life in gMG: a randomised, double-blinded, placebo-controlled, phase 3 trial (ADAPT)’ (Abstract #EPR-097) was presented at the European Academy of Neurology Congress 2022, 25–28 June 2022.

Disclosures: Francesco Saccà has participated in advisory boards for Alexion, Almirall, Argenx, Avexis, Biogen, Forward Pharma, Lexeo Therapeutics, Merk, Novartis, Novatek, Roche, Sanofi and Takeda; and received  honoraria from Alexion, Argenx, Biogen, Mylan, Novartis, Roche, Sanofi and Teva.

Support: Interview and filming supported by Touch Medical Media. Interview conducted by Lisa Glass.

Filmed as a highlight of EAN 2022.

Click here for more content on this topic.

Share
Facebook
X (formerly Twitter)
LinkedIn
Via Email
Mark CompleteCompleted
BookmarkBookmarked
Copy LinkLink Copied
Close Popup