Home > Andrew Feigin, AD/PD 2021: Results from the Phase 2 SIGNAL Trial
Alzheimer's Disease & Dementia, Huntington’s Disease

Andrew Feigin, AD/PD 2021: Results from the Phase 2 SIGNAL Trial

Published Online: March 17th 2021

We had the opportunity to meet with Andrew Feigin (Department of Neurology, NYU Grossman School of Medicine, New York City, NY, USA) to discuss the results from the phase 2 Huntington’s Disease trial of Anti-Semaphorin 4D Antibody Pepinemab (SIGNAL).

The abstract entitled ‘Results of Phase 2 Huntington’s Disease Trial of Anti-Semaphorin 4D Antibody Pepinemab (SIGNAL) will Guide Clinical Trial in Alzheimer’s Disease’ was presented at The 15th International Conference for Alzheimer’s & Parkinson’s Diseases (Virtual), March 8-14, 2021.

Questions:

  1. What is the rationale for blocking SEMA4D-induced inflammation in the treatment of Huntington’s Disease (HD) and Alzheimer’s Disease (AD)? (0:17)
  2. What did we learn from the SIGNAL trial of pepinemab in people with HD? (1:29)
  3. What will be the next steps in the clinical development of pepinemab in people with AD? (3:42)

Disclosures: Andrew Feigin has served as a consultant for NeuExcell, Prilenia, Stealth, and Voyager.

Support: Interview and filming supported by Touch Medical Media.

Filmed as a highlight of AD/PD Virtual 2021.

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