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Joseph Samaha, Jim Dagher, Shayan Abdollah Zadegan

Huntington’s disease (HD) is a neurodegenerative disease inherited in an autosomal dominant manner. It is caused by an expansion of cytosine, adenine, guanine (CAG) repeats within the huntingtin (HTT) gene, which is located on chromosome 4. This pathological expansion of CAG repeats results in the production of a mutant huntingtin protein with an abnormally long polyglutamine […]

Treatment Options for Pediatric Multiple Sclerosis:Brenda Banwell, MD

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Published Online: May 6th 2014

Brenda Banwell, MD, Chief, Division of Neurology, Professor of Neurology, Perelman School of Medicine at the University of Pennsylvania, said that there are 3 areas of treatment associated with pediatric multiple sclerosis (MS). The first is the treatment of the acute attack. The acute attack, or relapse, is treated the same in both pediatric and adult cases with corticosteroids or immunoglobulin. The second treatment area is chronic multiple sclerosis where first-line therapies are utilized like Interferon beta 1a, Interferon beta 1b, and glatiramer acetate. Finally, there is escalation therapy, which can be treated with natalizumab. International consensus guidelines and shared care models are used by clinicians to treat patients because there are no clinical trials for the treatment of pediatric MS today.

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