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Motor neuron synapses with muscle fiber via electrical impulse transmission and neurotransmitter release, forming neuromuscular junctions , motor neuron, neuroscience
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Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder of upper and lower motor neurons that results in progressive motor impairment. ALS is the most common disease of motor neurons with an annual incidence of approximately 1.7–2.5 per 100,000 people. It is a terminal condition with a typical life expectancy of 2–5 years from symptom onset. […]

Treatment Options for Pediatric Multiple Sclerosis:Brenda Banwell, MD

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Published Online: May 6th 2014

Brenda Banwell, MD, Chief, Division of Neurology, Professor of Neurology, Perelman School of Medicine at the University of Pennsylvania, said that there are 3 areas of treatment associated with pediatric multiple sclerosis (MS). The first is the treatment of the acute attack. The acute attack, or relapse, is treated the same in both pediatric and adult cases with corticosteroids or immunoglobulin. The second treatment area is chronic multiple sclerosis where first-line therapies are utilized like Interferon beta 1a, Interferon beta 1b, and glatiramer acetate. Finally, there is escalation therapy, which can be treated with natalizumab. International consensus guidelines and shared care models are used by clinicians to treat patients because there are no clinical trials for the treatment of pediatric MS today.

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