Neuropathic Pain
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An Introduction to Neuropathic Pain
Neuropathic pain is the result of an injury or illness that impacts the somatosensory system, responsible for the perception of touch, pain, pressure etc. arising from inside and the surface of the body. Common causes include amputation, chemotherapy, diabetes, multiple sclerosis and shingles. The multifactorial nature of the condition makes neuropathic pain challenging to diagnose and treat. Combination therapy is commonplace. Despite this, a high proportion of still patients fail to achieve adequate pain relief with manageable side effects. Multidisciplinary care is essential and includes nonopioid pharmacological management, interventional therapies, neurostimulation, low-dose opioid treatment and targeted drug-delivery therapy.
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Opioid therapy has become a mainstay for the treatment of chronic pain, despite evidence that these medications may be ineffective and even unsafe in this patient population.1,2 In patients with chronic back pain, the use of first-line medications (non-steroidal anti-inflammatory ...
Prof. Marc A. Russo President, International Neuromodulation Society Director of Hunter Pain Specialists, Hamilton Day Surgery Centre, Genesis Research Services, Broadmeadow, Australia Co-Director, Innervate Pain Management Program, Newcastle, Australia Chronic pain is a heterogenous, complex condition that is associated ...
Lateral epicondylitis, or tennis elbow, is pain in the lateral elbow as a result of repetitive forearm pronation and supination in elbow extension.1 It is a frequent cause of elbow pain, and affects 1–3% of the adult population every year, resulting ...
Neuropathic pain arises from injury to or disease in the somatosensory nervous system.1 Normal sensation and pain sensation are both impaired and patients may present with peculiar painful characteristics such as allodynia and hyperalgesia.2 Central neuropathic pain includes pain from ...
Proper intraoperative positioning is a simple, yet crucial, component of a successful operation. During each surgical procedure, a position should be employed, which not only meets the surgeon’s requirements, but also has the fewest disadvantages for the patient. Peripheral ...
An expert interview with Robert Bolash, Departments of Pain Management and Evidence Based Pain Research, Cleveland Clinic Lerner College of Medicine, Cleveland, OH, USA In this expert interview, Robert Bolash, an Assistant Professor of Anesthesiology in the Departments of Pain ...
Complex regional pain syndrome, type 1 (CRPS1)/reflex sympathetic dystrophy (RSD) is a neuropathic pain disorder,1 with pain reflecting partially damaged nerve fibers.2 It is normally caused by traumatic injury, further aggravated by neuroinflammation.3 The latter contributes to the devastating potential ...
Herpes zoster, also known as shingles, is one of the many manifestations of neurologic disorders and occurs with a cumulative life-time incidence of 10–20% in the general population.1 The annual incidence of this disease differs worldwide; in the UK, herpes zoster ...
Neuromyelitis optica spectrum disorder Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune inflammatory disease of the central nervous system (CNS) causing severe inflammation and demyelination of the optic nerve (optic neuritis [ON]), the spinal cord (transverse myelitis [TM]) and the ...
Acute pain is defined as an ‘unpleasant, complex, dynamic psychophysiological response to tissue damage, disease or inflammation’,1–3 and often lasts for a short period.1,4 Its biological function is to minimise behaviours that may lead to reduced tissue healing.1,5 When patients ...
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